Yunong Zhang
Yunong Zhang graduated as a master in Medicinal Chemistry at Jinan University in 2022, following her Bachelor’s degree obtained at Jinan University in 2019. She focused on discovery of aberrant kinase inhibitors with novel structures to exhibit promising anti-tumor efficacy in murine xenograft models under the guidance of Prof. Ke Ding.
Currently, she is working at the lab of Biocrystallography for macorcrystallography in Pharmaceutical Science and lab of Medicinal Chemistry in Rega Institute for Medical Research.
Her work involves fragment-based drug design of antivirals, including crystal growing, X-ray analysis as well as model building and medicinal synthesis.
Supervisor: Sergei Strelkov (KU Leuven) and co-supervisor: Peter Verwilst (KU Leuven)
CV
Research Interests
1. 1-Methyl-3-((4-(quinolin-4-yloxy)phenyl)amino)-1H-pyrazole-4-carboxamide derivatives as new rearranged during Transfection (RET) kinase inhibitors capable of suppressing resistant mutants in solvent-front regions
Yunong Zhang, Shinpan Chan, Rui He, Yiling Liu, Xiaojuan Song, Zheng-Chao Tu, Xiaomei Ren, Yang Zhou, Zhang Zhang, Zhen Wang, Fengtao Zhou, Ke Ding, European Journal of Medicinal Chemistry 2022, 244, 114862. Read here
2. Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors
Shingpan Chan, Yunong Zhang, Jie Wang, Qiuchun Yu, Xia Peng, Jian Zou, Licheng Zhou, Li Tan,
Yunxin Duan, Yang Zhou, Hoon Hur, Jing Ai, Zhen Wang, Xiaomei Ren, Zhang Zhang, Ke Ding, Molecules 2022, 65, 15374–15390. Read here