Xujie Zhang
Xujie Zhang graduated as a Master in Medicinal Chemistry at Shandong University in 2023, following his Bachelor's degree obtained at Shandong University in 2020. During his Master’s studies, he focused on the discovery of the HIV capsid inhibitors binding at the protein-protein interface with novel structures and mechanisms under the guidance of Prof. Peng Zhan. Currently, he is working at the Rega Institute for Medical Research.
Xujie is currently developping small-molecule inhibitors and PROTACs for a cancer-causing transcription factor. His work involves fragment-based design and synthesis of new molecular entities.
Co-supervisors: Prof. Sergei Strelkov (KUL) and Prof. Zeger Debyser (KUL).
CV
Research Interests
1. 5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
Lin Sun, Ping Gao, Guanyu Dong, Xujie Zhang, Xiqiang Cheng, Xiao Ding, Xueshun Wang, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Luis Menéndez-Arias, Peng Zhan, Xinyong Liu, European Journal of Medicinal Chemistry 2018, 155, 714–724. Read here
2. An insight on medicinal aspects of novel HIV-1 capsid protein inhibitors
Lin Sun, Xujie Zhang, Shujing Xu, Tianguang Huang, Shu Song, Srinivasulu Cherukupalli, Peng Zhan, Xinyong Liu, European Journal of Medicinal Chemistry 2021, 217, 113380. Read here
3. Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries
Yucen Tao, Xia Hao, Lanlan Jing, Lin Sun, Srinivasulu Cherukupalli, Shugong Liu, Gaochan Wu, Shujing Xu, Xujie Zhang, Xiaoyu Shi, Yuning Song, Xinyong Liu, Peng Zhan, Bioorganic Chemistry 2021, 115, 105254. Read here
4. Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors
Xujie Zhang,† Lin Sun,† Megan E. Meuser, Waleed A. Zalloum, Shujing Xu, Tianguang Huang, Srinivasulu Cherukupalli, Xiangyi Jiang, Xiao Ding, Yucen Tao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Simon Cocklin, Xinyong Liu, Peng Zhan, European Journal of Medicinal Chemistry 2021, 226, 113848. Read here
5. Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors
Shujing Xu, Shu Song, Lin Sun, Ping Gao, Shenghua Gao, Yue Ma, Dongwei Kang, Yusen Cheng, Xujie Zhang, Srinivasulu Cherukupalli, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan, Bioorganic & Medicinal Chemistry 2022, 53, 116531. Read here
6. The current progress in the use of boron as a platform for novel antiviral drug design
Shuo Wang, Yujie Ren, Zhao Wang, Xiangyi Jiang, Shujing Xu, Xujie Zhang, Shujie Zhao, Waleed A Zalloum, Xinyong Liu, Peng Zhan, Expert Opinion on Drug Discovery 2022, 17, 1329–1340. Read here
7. Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability
Shujing Xu, Lin Sun, Alexej Dick, Waleed A. Zalloum, Tianguang Huang, Megan E. Meuser, Xujie Zhang, Yucen Tao, Srinivasulu Cherukupalli, Dang Ding, Xiao Ding, Shenghua Gao, Xiangyi Jiang, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Xinyong Liu, Peng Zhan, European Journal of Medicinal Chemistry 2022, 227, 113903. Read here
8. Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary
Shujing Xu, Dang Ding, Xujie Zhang, Lin Sun, Dongwei Kang, Boshi Huang, Xinyong Liu, Peng Zhan, Molecules 2022, 27, 850. Read here
9. HIV-1 capsid inhibitors: a sword to destroy the virus
Xujie Zhang, Shujing Xu, Lin Sun, Dang Ding, Yucen Tao, Dongwei Kang, Xinyong Liu, Peng Zhan, Future Medicinal Chemistry 2022, 14, 605–607. Read here
10. Discovery of Bioactive Molecules via Miniaturized Parallel Modular Reactions and Rapid Screening (2016-2021 Update)
Yucen Tao, Shujing Xu, Xujie Zhang, Xinyong Liu, Peng Zhan, Mini-Reviews in Organic Chemistry 2022, 19, 546–548. Read here
11. Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes
Shujing Xu, Lin Sun, Dang Ding, Xujie Zhang, Xinyong Liu, Peng Zhan, Metabolites 2022, 12, 752. Read here
12. Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778
Xiangkai Ji, Xiangyi Jiang, Chisa Kobayashi, Yujie Ren, Lide Hu, Zhen Gao, Dongwei Kang, Ruifang Jia, Xujie Zhang, Shujie Zhao, Koichi Watashi, Xinyong Liu, Peng Zhan, Molecules 2022, 27, 5987. Read here
13. Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators
Xujie Zhang,† Lin Sun,† Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan, Molecules 2022, 27, 7640. Read here
14. Application of Multi-component Reactions in the Search of Bioactive Molecules
Shujing Xu, Xujie Zhang, Yucen Tao, Xinyong Liu, Peng Zhan, Mini-Reviews in Organic Chemistry 2022, 19, 894–897. Read here
15. Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein
Xiangyi Jiang, Prem Prakash Sharma, Brijesh Rathi, Xiangkai Ji, Lide Hu, Zhen Gao, Dongwei Kang, Zhao Wang, Minghui Xie, Shujing Xu, Xujie Zhang, Erik De Clercq, Simon Cocklin, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan, Journal of Medical Virology 2022, 94, 5975–5986. Read here
16. Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators
Shuo Wang, Yujie Ren, Qilan Li, Ya Wang, Xiangyi Jiang, Shujing Xu, Xujie Zhang, Shujie Zhao, Daniel P. Bradley, Molly E. Woodson, Fabao Zhao, Shuo Wu, Yuhuan Li, Ye Tian, Xinyong Liu, John E. Tavis, Peng Zhan, Bioorganic Chemistry 2022, 129, 106192. Read here
17. Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators
Shujing Xu, Lin Sun, Waleed A. Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan, Molecules 2022, 27, 8415. Read here
18. Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors
Jian Zhang, Yue Dong, Shenghua Gao, Xujie Zhang, Hui Liao, Xiaoyu Shi, Zhijiao Zhang, Tong Zhao, Ruipeng Liang, Danhui Qi, Ting Wu, Jianxin Pang, Xinyong Liu, Peng Zhan, European Journal of Medicinal Chemistry 2022, 244, 114816. Read here
19. The discovery and design of novel HIV-1 capsid modulators and future perspectives
Dang Ding, Shujing Xu, Xujie Zhang, Xiangyi Jiang, Simon Cocklin, Alexej Dick, Peng Zhan, Xinyong Liu, Expert Opinion on Drug Discovery 2023, 18, 5–12. Read here
20. From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface
Shujing Xu, Lin Sun, Waleed A. Zalloum, Xujie Zhang, Tianguang Huang, Dang Ding, Yucen Tao, Fabao Zhao, Shenghua Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Simon Cocklin, Xinyong Liu, Peng Zhan, Chinese Chemical Letters 2023, 34, 107611. Read here
21. Computer-aided drug design in seeking viral capsid modulators
Shujie Zhao, Xujie Zhang, Edeildo Ferreira da Silva-Júnior, Peng Zhan, Xinyong Liu, Drug Discovery Today 2023, 28, 103581. Read here
22. Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators
Xujie Zhang,† Lin Sun,† Shujing Xu, Tianguang Huang, Fabao Zhao, Dang Ding, Chuanfeng Liu, Xiangyi Jiang, Yucen Tao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Alexej Dick, Xinyong Liu, Peng Zhan, RSC Medicinal Chemistry 2023, 14, 1272−1295. Read here